PUBLICATIONS

SCIENTIFIC PAPERS

2024

Minor changes to circulating steroid hormones in female rats after perinatal exposure to diethylstilbestrol or ketoconazole

Reduced ovarian cholesterol and steroid biosynthesis along with increased inflammation are associated with high DEHP metabolite levels in human ovarian follicular fluids

In-depth analysis of transcriptomes in ovarian cortical follicles from children and adults reveals interfollicular heterogeneity

Ketoconazole blocks progesterone production without affecting other parameters of cumulus-oocyte complex maturation.

Effects of chemical in vitro activation vs fragmentation on human ovarian tissue and follicle growth in culture.

Persistent organic pollutants dysregulate energy homeostasis in human ovaries in vitro

The profile of steroid hormones in fetal and adult ovaries.

2023

Perinatal exposure to the fungicide ketoconazole alters hypothalamic control of puberty in female rats.

Quantitative analysis of ovarian surface photographs as a tool for assessment of chemical effects on folliculogenesis and ovulation in rats.

Comparison of female rat reproductive effects of pubertal versus adult exposure to known endocrine disruptors.

A method for in vitro data and structure curation to optimize for QSAR modelling of minimum absolute potency levels and a comparative use case.

Transcriptional profiling of the developing rat ovary following intrauterine exposure to the endocrine disruptors diethylstilbestrol and ketoconazole.

Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models.

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DATA SETS

E-ovary. Cell types in adult human ovaries. 

 

CONFERENCE ABSTRACTS

Characterisation of the effects of Ketoconazole and Diethylstilbestrol on the human fetal adrenal. Laetitia Lecante et al. ICT 2022 [abstract]

The bovine model of in vitro oocyte maturation has a potential application in the screening of EDCs eliciting reproductive toxicity via oocyte effects; diethylstilbestrol as the showcase compound. Nadia Asimaki et al. ICT 2022 [abstract]

The H295R steroidogenesis assay does not reflect ovarian steroidogenesis: implications for identification of EDCs toxic to female reproduction. Evi Vazakidou et al. ICT 2022 [abstract]

Characterization of the effects of the steroidogenesis inhibitor Ketoconazole on the human fetal ovary. Pauline Lelandais et al., EUROTOX 2021 [abstract]

Expanding the H295R steroidogenic assay using LC-MS/MS and an ER-alpha reporter gene assay as read-outs using azole fungicides as test compounds. Evi Vazakidou et al., EUROTOX 2021 [abstract]

Disruption of estrogenic and androgenic bio activities in human foetuses exposed to maternal smoking. Chiara Talia et al., ENDO 2021 [abstract]

RECORDINGS

Webinar featuring Paul Fowler – Maternal exposure to air pollution nanoparticles and adverse birth outcomes, January 19, 2023

Why Plastic?, We The Guinea Pigs with Terje Svingen, Hanna Johansson and Ana Soto. BBC World News. 12 February 2022.

Webinar and panel discussion with Dr. Shanna Swan for the European release of her book “Count Down”. 15 March 2021.

FREIA project highlights by Majorie van Duursen. EURION Annual Meeting January 2021.

Majorie van Duursen presents the FREIA project at the Second Annual Forum on Endocrine Disruptors. 17-18 December 2020.

Pauliina Damdimopoulou – Chemicals and fertility in women – lessons from One Health. Helsinki One Health, 23 Oct 2020. Key Note Lecture.

Podcast featuring Paul Fowler – Hormones: the inside story. Are everyday chemicals harming my health?

REPORTS

Report with presentation of Majorie van Duursen at the Second Annual Forum on Endocrine Disruptors. December 17-18, 2020.

Plastics, EDCs & Health. An Authoritative guide. The Endocrine Society and IPEN (International Pollutants Elimination Network), co-authored by Pauliina Damdimopoulou. December 10, 2020.

OTHER MEDIA

Let’s talk about how the chemicals in cosmetics could affect fertility. Health Europa. February 5 2019.

Interview with the project coordinator in Dutch national news paper. Article is in Dutch. NRC, March 4 2019.